RecruitingNot Applicable

Interaction Between Early Trauma and Odor-induced Dopamine Release

France30 participantsStarted 2026-04-27

Plain-language summary

This prospective, double-blind, parallel-group controlled trial aims to investigate the consequence of early trauma on dopamine release evoked by positive valence odors.

Who can participate

Age range

18 Years – 30 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Aged 18 years or older * Have been selected based on the Childhood Trauma Questionnaire score * Non-smoker * Be able to speak and read French * Sign a consent form before intervention. Exclusion Criteria: * A pre-existing condition that affects olfaction including congenital anosmia, upper respiratory tract infection, nasal and/or sinus disease, * Be on medication, with the exception of oral contraceptives * Pregnant or breast-feeding woman (check with urine pregnancy tests); * Contraindications to TMS or MRI (implanted medical devices or metallic foreign body in the head); * Psychiatric disorders * Use of psychotropic drugs * Have participated in a study involving the injection of a radiotracer during the year

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Dopamine transmission measured with positron emission tomography

Timeframe: 24 months

Trial details

NCT IDNCT06284382

SponsorHôpital le Vinatier

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2028-04-27

Contact for this trial

FILIPE GALVAO

0033437915565 filipe.galvao@ch-le-vinatier.fr

View on ClinicalTrials.gov More Trauma, Psychological trials

Who can participate

Age range

18 Years – 30 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.