CHARGE is a hybrid type I feasibility study to compare a choice architecture intervention for cascade genetic testing to usual care.
Who can participate
Age range18 Years
SexALL
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Proband Inclusion Criteria:
* Have a newly reported pathogenic or likely pathogenic variant in one or more of the following genes: APC, ATM, BRCA1, BRCA2, CDH1, CHEK2, PALB2, MLH1, MSH2, MSH6, PMS2, PTEN, TP53
* 18 years of age or older
* English fluency
* Have at least 1 adult living genetically related relative who resides in Texas
Proband Exclusion Criteria:
* Referred for genetic testing by a relative with a pathogenic variant
* Unwilling to be randomized to a study arm
Relative Inclusion Criteria:
* 18 years of age or older
* English fluency
* Residing in Texas
What they're measuring
1
Rate of cascade genetic testing
Timeframe: 3-6 months
Trial details
NCT IDNCT06284330
SponsorUniversity of Texas Southwestern Medical Center