HONEY for the Treatment of POst-Tonsillectomy Pain (NCT06275698) | Clinical Trial Compass
RecruitingNot Applicable
HONEY for the Treatment of POst-Tonsillectomy Pain
United Kingdom100 participantsStarted 2023-09-04
Plain-language summary
Double-blind, randomised, placebo controlled, single-site trial in adults to compare the effect of Manuka honey with standard of care compared to placebo with standard of care on post-tonsillectomy pain and postoperative outcomes.
Main aim is to investigate a potential improvement in post-tonsillectomy pain control, with a low cost and freely available alternative to conventional analgesics. Recent systematic review and multidisciplinary consensus suggest a potential role for the inclusion of honey for this purpose. Clinical efficacy over placebo remains to be conclusively demonstrated in robust clinical trials.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adult (≥18years old at the time of giving consent)
* Consented and listed for bilateral tonsillectomy or adenotonsillectomy
* Tonsillectomy performed within the trial study period
Exclusion Criteria:
* Any concurrent Head \& Neck (H\&N) malignancy
* Unilateral tonsillectomy
* Pregnancy
* Concurrent pharyngeal or upper aerodigestive tract biopsy
* Robotic tonsillectomy
* Previous H\&N malignancy
* Previous H\&N radiotherapy
* Type 1/2 diabetes mellitus
* Known allergy to bee related products
* Known allergy to golden syrup
* History of chronic pain
* History of fibromyalgia
* Current usage of chronic (\>6weeks) analgesia
* High-risk anaesthetic patients
* Children or adolescents \<18years old
* Adults unable to consent for themselves
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.