RecruitingNot Applicable

Standby Cannulated ECMO for High-Risk Percutaneous Coronary Intervention

China176 participantsStarted 2025-03-21

Plain-language summary

The goal of this multicenter, randomized trial is to compare standby cannulated ECMO versus prophylactic ECMO in patients undergoing high-risk percutaneous coronary intervention (PCI). The main question it aims to answer is : • If standby cannulated ECMO as compared with prophylactic ECMO will improve the outcomes in patients undergoing high-risk PCI

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. Clinicians decide to perform PCI during ECMO support.
✓. Age of ≥18
✓. Patient presents with a compromised ejection fraction of less than 35% or at risk of hemodynamic deterioration, or intervention on the last patent coronary conduit or an unprotected left main artery, or complex 3-vessel disease (SYNTAX score of ≥33)
✓. Informed consent

Exclusion criteria

✕. Subject in cardiogenic shock(need inotrope, pressor or mechanical support to maintain SBP \>90mmHg)
✕. Presence of moderate to severe aortic insufficiency
✕. Severe peripheral vascular disease
✕. creatinine≥4mg/dL
✕. Liver dysfunction with elevation of liver enzymes and bilirubin levels to ≥ 3x ULN
✕. History of recent (within 1 month) stroke or TIA
✕. Abnormal coagulation(defined as platelet count ≤50000/mm3 or Fibrinogen ≤1.50g/L)
✕. Allergy or intolerance to heparin, aspirin, ADP receptor inhibitors, or documented heparin induced thrombocytopenia.

What they're measuring

Composite rate of 9 major adverse events

Timeframe: 30 days

Trial details

NCT IDNCT06274411

SponsorBeijing Anzhen Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-11-01

Contact for this trial

Xiaotong Hou, MD

010-64456631 xt.hou@ccmu.edu.cn

View on ClinicalTrials.gov More ECMO trials