Neuromodulation to Reduce Muscle Stiffness Following Spinal Cord Injury

Inclusion criteria: * Age 18 years or older * History of spinal cord injury * Time since diagnosis longer than six months * Presence of spasticity in the lower limbs (≥ 3 on the Numerical Rating Scale of Spasticity Severity \[range from 0 to 10\]) * If needed, agreement to reduce antispastic medication Exclusion criteria: * Neurological level of spinal cord injury below T11 * Ventilatory-dependent * Change in neurological status over the past 2 months * Rigidity, contraction, or passive range of motion of less than 40 deg in both knee joints * Botulinum toxin injections in lower extremities in the previous 3 months before enrollment * Systolic blood pressure at rest lower than 90 mm Hg * Implanted active devices (e.g., intrathecal baclofen pumps) * Passive implants (plates, screws) between T11 and L2 vertebras * Skin conditions precluding placement of electrodes * Pressure ulcers stage 2 or higher on the gluteal area or lower extremities * Receiving antibiotics for infections * Pregnancy * Difficulty following instructions * Participation in another study with investigational drugs or devices within the 30 days preceding and during the present study * Other medical risks/contraindications as determined by the study physicians