CompletedNot Applicable

Comparison of Effects of Scalp Block and Intravenous Esmolol on Hemodynamic Response Following the Skull Pins Application for Elective Supratentorial Craniotomy

Thailand90 participantsStarted 2022-09-19

Plain-language summary

The goal of this clinical trial is to compare hemodynamic response (MAP, SBP, DBP and HR) between scalp block and intravenous esmolol while skull pins application in patients undergoing elective supratentorial craniotomy under general anesthesia.

Who can participate

Age range18 Years – 65 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age 18-65 years old * BMI 18-30 kg/m2 * American Society of Anesthesiologists (ASA) status I-III * Elective supratentorial craniotomy under general anesthesia * Required application of skull pins Exclusion Criteria: * Poor controlled hypertensive condition (Baseline BP ≥ 160/110 mmHg) * Thrombocytopenia / Coagulopathy * Preoperative atrioventricular block (More than 2nd degree AV block) * Emergency surgery * Posterior fossa / Intracranial aneurysm surgery * Pregnancy * Chronic use of pain control * Contraindication to beta-blockers * Allergy to the drugs used in the study

What they're measuring

MAP

Timeframe: Baseline, 1 minute before skull pins, then 30 sec, 60 sec, 90 sec, 120 sec, 180 sec and 300 sec after skull pins

SBP

Timeframe: Baseline, 1 minute before skull pins, then 30 sec, 60 sec, 90 sec, 120 sec, 180 sec and 300 sec after skull pins

DBP

Timeframe: Baseline, 1 minute before skull pins, then 30 sec, 60 sec, 90 sec, 120 sec, 180 sec and 300 sec after skull pins

Trial details

NCT IDNCT06268275

SponsorKhon Kaen University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-02-01

View on ClinicalTrials.gov More Hemodynamic Instability trials

Who can participate

Age range18 Years – 65 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

MAP

Timeframe: Baseline, 1 minute before skull pins, then 30 sec, 60 sec, 90 sec, 120 sec, 180 sec and 300 sec after skull pins

SBP

Timeframe: Baseline, 1 minute before skull pins, then 30 sec, 60 sec, 90 sec, 120 sec, 180 sec and 300 sec after skull pins

DBP

Timeframe: Baseline, 1 minute before skull pins, then 30 sec, 60 sec, 90 sec, 120 sec, 180 sec and 300 sec after skull pins