CompletedNot Applicable

Ulinastatin Improves Post-Cardiac Surgery Cognitive Dysfunction

China7,065 participantsStarted 2015-01-01

Plain-language summary

The study comprised two primary components: a retrospective analysis of clinical big data and a conventional prospective cohort study involving patients undergoing cardiac surgery. The objectives were: 1. To assess the preventive effect of ursodeoxycholic acid on post-cardiac surgery cognitive dysfunction over an eight-year period. 2. To analyze preoperative and postoperative 24-hour plasma samples from prior studies to quantify the levels of glycocalyx and its associated regulatory factors. 3. To evaluate the clinical association between the measured parameters and patient outcomes.

Who can participate

Age range18 Years – 80 Years

SexALL

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Inclusion criteria

✓. Voluntary participation in the study;
✓. Age ≥ 18 years and ≤ 80 years;
✓. Patients undergoing heart surgery: (coronary artery bypass grafting, heart valve replacement surgery, Morrow procedure, aortic dissection surgery).

Exclusion criteria

✕. Patients experiencing adverse events during the surgery;
✕. Recipients of solid organ or bone marrow transplants;
✕. Patients with autoimmune diseases, tumors, or who have received high-dose steroids or immunosuppressive therapy within the past 2 months;
✕. Deemed unsuitable for participation in this study by the researchers.

What they're measuring

POCD - Postoperative Cognitive Dysfunction

Timeframe: 24 hours

POD-postoperative delirium

Timeframe: 7 days

Trial details

NCT IDNCT06268249

SponsorQin Zhang

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2022-12-30

View on ClinicalTrials.gov More Postoperative Cognitive Dysfunction trials