Prophylactic Endobronchial Tranexamic Acid to Reduce Bleeding in Transbronchial Cryobiopsy (NCT06266546) | Clinical Trial Compass
Active — Not RecruitingPhase 3
Prophylactic Endobronchial Tranexamic Acid to Reduce Bleeding in Transbronchial Cryobiopsy
United States100 participantsStarted 2024-03-01
Plain-language summary
Transbronchial cryobiopsies are common procedures used to obtain tissue samples from airways for diagnostic purposes. While these procedures are safe, there is a risk of bleeding from the biopsy site. We are conducting a research study to assess the safety and effectiveness of using tranexamic acid prior to undergoing a transbronchial cryobiopsy.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age ≥18
* Signed informed consent
* Receiving a transbronchial cryobiopsy
Exclusion Criteria:
* Age below 18
* Pregnancy
* Bleeding diathesis (INR \>1.5 or known hematological problems)
* Subarachnoid hemorrhage
* Any active bleeding (any site)
* Decompensated liver disease
* Active intravascular clotting
* Prior VTE
* On oral contraceptive therapy
* Platelet count less than 50,000
* Use of antiplatelet medication other than low-dose aspirin within 5 days of procedure
* Use of therapeutic anticoagulation within the last 24 hrs
* Known severe pulmonary hypertension (pulmonary artery systolic pressure \> 60 mmHg)
* Chronic renal failure (estimated GFR below 30 mL/min)
* Allergy or hypersensitivity to tranexamic acid or any of its ingredients
* Prisoners
* Comfort care planned or initiated within 72 hours of admission
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.