This study will compare the effectiveness of two different treatments for preventing infection from frostbite injuries. These two treatments are A) aloe vera and B) long-acting silver wound dressings. The investigators will also study the safety and effectiveness of Dalbavancin, an FDA approved antibiotic used for treating people who develop frostbite wound infections, as well as evaluate how frostbite damage to individuals' bodies may affect how fast their kidney clear drugs from their systems.
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The number of positive microbial wound cultures on admission
Timeframe: Admission
The number of positive microbial wound cultures on hospital day 4
Timeframe: Hospital Day 4
The number of positive microbial wound cultures on hospital day 8
Timeframe: Hospital Day 8
The number of positive microbial wound cultures on hospital day 12
Timeframe: Hospital Day 12
The number of positive microbial wound cultures on hospital day 16
Timeframe: Hospital Day 16
The number of positive microbial wound cultures on hospital day 20
Timeframe: Hospital Day 20
The number of positive microbial wound cultures on hospital day 24
Timeframe: Hospital Day 24
The number of positive microbial wound cultures on hospital day 28
Timeframe: Hospital Day 28
The number of positive microbial wound cultures on hospital day 32
Timeframe: Hospital Day 32
The number of positive microbial wound cultures on hospital day 36
Timeframe: Hospital Day 36
The number of positive microbial wound cultures on hospital day 40
Timeframe: Hospital Day 40
The number of positive microbial wound cultures on hospital day 44
Timeframe: Hospital Day 44
The number of positive microbial wound cultures on hospital day 48
Timeframe: Hospital Day 48
The number of positive microbial wound cultures on hospital day 52
Timeframe: Hospital Day 52
The number of positive microbial wound cultures on hospital day 56
Timeframe: Hospital Day 56
The number of positive microbial wound cultures on hospital day 60
Timeframe: Hospital Day 60
Number of gram positive cultures at admission
Timeframe: Admission
Number of gram positive cultures on hospital day 4
Timeframe: Hospital Day 4
Number of gram positive cultures on hospital day 8
Timeframe: Hospital Day 8
Number of gram positive cultures on hospital day 12
Timeframe: Hospital Day 12
Number of gram positive cultures on hospital day 16
Timeframe: Hospital Day 16
Number of gram positive cultures on hospital day 20
Timeframe: Hospital Day 20
Number of gram positive cultures on hospital day 24
Timeframe: Hospital Day 24
Number of gram positive cultures on hospital day 28
Timeframe: Hospital Day 28
Number of gram positive cultures on hospital day 32
Timeframe: Hospital Day 32
Number of gram positive cultures on hospital day 36
Timeframe: Hospital Day 36
Number of gram positive cultures on hospital day 40
Timeframe: Hospital Day 40
Number of gram positive cultures on hospital day 44
Timeframe: Hospital Day 44
Number of gram positive cultures on hospital day 48
Timeframe: Hospital Day 48
Number of gram positive cultures on hospital day 52
Timeframe: Hospital Day 52
Number of gram positive cultures on hospital day 56
Timeframe: Hospital Day 56
Number of gram positive cultures on hospital day 60
Timeframe: Hospital Day 60
Change in serum concentration of dalbavancin in plasma (mcg/ml) over time
Timeframe: 1, 4, 12 hours, and 1,2,3,4,6,8,10,13,16 (or date of discharge if earlier) days post dalbavancin infusion
Dalbavancin concentrations in subcutaneous tissue
Timeframe: Up to 12 weeks
Change in presence of Augmented Renal Clearance
Timeframe: Baseline, Up to 12 weeks