Lenvatinib Plus DEB-TACE With/Without FOLFOX-HAIC for Large HCC With PVTT

Inclusion Criteria: * a confirmed diagnosis of HCC * the largest intrahepatic lesion \>7 cm * presence of major PVTT on imaging * Eastern Cooperative Oncology Group performance status ≤1 * Child-Pugh class A/B * adequate hematologic and organ function, with leukocyte count 3.0 109/L, neutrophil count 1.5 109/L, platelet count 75 109/L, hemoglobin 85 g/L, alanine transaminase and aspartate transaminase 5 upper limit of the normal, creatinine clearance rate 1.5 upper limit of the normal, and prothrombin time prolongation \<4 s Exclusion Criteria: * incomplete medical records * central nervous system involvement * previous treatment with transarterial embolization, TACE, HAIC, radiotherapy, or systemic therapy * history of malignancies other than HCC * history of organ transplantation * severe cardiac, pulmonary or renal dysfunction