The goal of this observational study is to evaluate non-surgical periodontal treatment in women and men with periodontitis with and without obesity. The main questions it aims to answer are: * If non-surgical periodontal treatment of patients with chronic periodontitis can modulate the innate and adaptive immune response taking into account patient gender and the coexistence of obesity * If there are specific miRNAs that can regulate this immune response and can be considered as suitable biomarkers and therapeutic targets. Obese or non-obese participants with periodontitis will receive non-surgical periodontal treatment, consisting of oral health guidance and mechanical periodontal debridement throughout the mouth using an ultrasonic device and manual curettes. Researchers will compare four groups: obese women, non-obese women, obese men, and non-obese men, to clarify the involment of immune response after treatment, considering the coexistence of obesity and potential gender differences.
Age range
18 Years – 69 Years
Sex
ALL
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Changes in inflammasome complex activation grade in patients with chronic periodontitis with and without obesity, before and after non-surgical periodontal treatment.
Timeframe: At recruitment
Changes in endothelial function in the study population.
Timeframe: At recruitment
Changes in endothelial function at molecular level in the study population.
Timeframe: At recruitment
Changes in the systemic inflammation status in the study population.
Timeframe: At recruitment
Changes in the expression of genes related to inflammatory pathways in PBMC in the study population.
Timeframe: At recruitment
Changes in the expression of genes related to oxidative stress levels in PBMC in the study population.
Timeframe: At recruitment
Changes in the expression of genes related to cellular respiration in PBMC in the study population.
Timeframe: At recruitment
Sequence miRNAs in biological fluids in patients with chronic periodontitis with and without obesity, before and after non-surgical periodontal treatment.
Timeframe: At recruitment
Evaluate the distribution and phenotype of different T lymphocyte and monocyte subpopulations in the study population.
Timeframe: At recruitment