CompletedNot Applicable

Association Between Lifetime Physical Activity and Exercise and the Development of Wild-type Transthyretin Amyloid Cardiomyopathy

Austria180 participantsStarted 2024-02-16

Plain-language summary

The aim of this study is to investigate the association between increased lifetime physical activity and the development of wild-type transthyretin amyloid cardiomyopathy.

Who can participate

Age range60 Years

SexALL

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Inclusion criteria

✓. Confirmed diagnosis of wtATTR-CM including sequencing of the TTR gene; or HF; or healthy proband without a diagnosis of heart disease\*
✓. Initial diagnosis of respective cardiac disease (wtATTR-CM, HF) after the 6th decade of life; or no cardiac disease (healthy control)
✓. Willingness and ability to provide signed informed consent form (ICF)
✓. Age \> 60 years

Exclusion criteria

✕. History of severe chronic illness limiting the ability to perform physical activity during the 3rd to 6th decade
✕. A diagnosis of dementia or cognitive impairment
✕. Any other reason resulting in the inability to perform the questionnaire and/or interview
✕. Known disease-causing variant (pathogenic or likely-pathogenic) in the TTR gene

What they're measuring

Association between lifetime physical activity (in METs) and disease development

Timeframe: 3rd to 6th decade

Trial details

NCT IDNCT06261216

SponsorMedical University of Graz

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-11-20

View on ClinicalTrials.gov More Amyloid Cardiomyopathy trials