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Cognitive Disorders in Hereditary Spastic Paraplegia Type 4

France30 participantsStarted 2022-01-01

Plain-language summary

Hereditary spastic paraplegia type 4 is the most frequent mutation of hereditary spastic paraplegias. It is commonly described as pure, with progressive weakness of the lower limbs, pyramidal syndrome and vesico-sphincter disorders. However, cognitive disorders have been reported for over 20 years, but remain poorly characterized.

Who can participate

SexALL

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Inclusion Criteria: * Patient over 18 years of age, living in the Grand Est region (France) * Patient with a pathogenic or probably pathogenic variant (class 4 or 5) in the SPAST gene. Exclusion Criteria: * dementia comorbidities or cognitive disorders unrelated to the pathology that may affect neuropsychological tests.

What they're measuring

cognitive testing

Timeframe: baseline

Trial details

NCT IDNCT06260982

SponsorCentral Hospital, Nancy, France

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-01

Contact for this trial

Mathilde Renaud

+333 83 85 17 80 m.renaud2@chru-nancy.fr

View on ClinicalTrials.gov More Spastic Paraplegia trials