MuSK Myasthenia 1000 Study (NCT06259071) | Clinical Trial Compass
RecruitingNot Applicable
MuSK Myasthenia 1000 Study
United States1,000 participantsStarted 2023-08-23
Plain-language summary
The MuSK myasthenia gravis 1000 study seeks to collect saliva samples from 1000 subjects with laboratory confirmed diagnosis of MuSK myasthenia to identify genetic variations associated with MuSK MG. The data collected may be used by researchers to gain a better understanding of the cause of MuSK MG and to identify biomarkers and targeted therapy for MuSK MG.
Who can participate
Age range
7 Years – 99 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Lab test confirming diagnosis of MuSK myasthenia gravis
* Willingness to provide saliva sample via mail or in person
Exclusion Criteria:
* Inability to provide informed consent
* Unwillingness to provide lab results of elevated muscle specific kinase antibody
* Unwillingness to provide saliva sample
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This study is focused specifically on MuSK myasthenia gravis rather than all types of MG — does my diagnosis confirm I have the MuSK antibody subtype, and would that make me a potential candidate worth discussing with my care team?
2Since this is a GWAS study, meaning it's looking at genetic patterns across a large group of patients rather than testing a new treatment, can you help me understand what participating would actually involve — like blood draws or genetic sample collection — and whether there are any real risks to me?
3Because this is a genetic research study and not a drug trial, it won't directly change my treatment — so should I be pursuing this alongside standard MuSK MG therapies, or is there a reason to prioritize one over the other right now?
4What could the findings from a genome-wide association study like this one eventually mean for people with MuSK MG — could it lead to better treatments or more personalized care down the road, even if it doesn't help me immediately?
5Are there other MuSK MG studies or registries currently recruiting that might offer more direct therapeutic benefit, and how does participating in this genetic study compare to those options?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.