The investigators aim to develop a clinically validated, histological acute tubular injury (ATI) scoring system to help improve diagnostic precision and predict clinical outcomes following ATI. To use an unbiased, data-driven approach, correlating pathological features (including digital pathology), key signatures using spatial technologies (transcriptomics or proteinomics) with relevant clinical outcomes. Spatial technologies (including spatial transcriptomics and spatial proteinomics) allow the use of 'precision pathology' to study the critical link between molecular characteristics to histological structure.
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Histopathology characteristics of acute tubular injury (ATI)
Timeframe: Specific for the biopsy/tissue, no time frame after
Kidney function
Timeframe: At biopsy (time 0) or during study follow up after biopsy (expected average 12-months)
Correlation of biopsy findings with kidney function at time of biopsy and longitudinally
Timeframe: At biopsy (time 0) or during study follow up after biopsy (expected average 12-months)