This is a pilot study in 10 men to test the hypothesis that perturbations in substrate flux and the circulating metabolic and pro-inflammatory milieus during a high-fat diet paradigm will modulate DNA methylation of genes in sperm associated with obesity and cardiometabolic dysfunction.
Age range
20 Years – 35 Years
Sex
MALE
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Sperm DNA methylation
Timeframe: Baseline, Immediately after the healthy diet, Immediately after the high-fat diet