Reducing Heart Failure Risk in Late-Life With Physical Activity (NCT06247774) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Reducing Heart Failure Risk in Late-Life With Physical Activity
42 participantsStarted 2026-06
Plain-language summary
The goal of this clinical trial is to learn about the molecular pathways associated with the benefit of a regular exercise program in patients with high blood pressure and who don't already participate in regular exercise.
The main question it aims to answer is to identify protein signatures associated with the benefits of a cardiac rehabilitation exercise program.
The trial will enroll 42 participants, who will be randomized to a 12 week cardiac rehabilitation exercise program versus control arm and asked to participate in the following at the beginning and end of study:
* Cardiopulmonary exercise test (CPET)
* Echocardiogram
* Physical function test
* 6-minute walk test
* Hand grip strength
* Quality of life questionnaire
* Blood draws
Researchers will compare results between those who do and don't participate in the exercise program.
Who can participate
Age range
65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Hypertension (controlled on stable medication regimen)
* Structural heart abnormality (LVH or LA enlargement)
* LVEF \> 50%
* Sedentary
* BMI \<30
Exclusion Criteria:
* Diabetes
* Unable to exercise
* Supplemental oxygen use
* Pulmonary hypertension
* Sleep apnea
* Regular exercise training
* Devices that limit ability to achieve target heart rate
* Moderate to severe valve disease
* Recent (within 3 months) major CV event or planned procedures (within 6 months)
* Terminal illness, life expectancy \<6 months
* Inability or unwillingness to comply with study requirements
* No access to smart phone/tablet
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Impact of Cardiac Rehabilitation training on single protein changes