Adjuvant Tebentafusp in High Risk Ocular Melanoma

Inclusion Criteria: * Primary non-metastatic UM, except iris melanoma, after definitive treatment either by surgery or radiotherapy * Time from primary treatment smaller than 11 weeks (note that the maximum time between primary treatment and randomization is 12 weeks ) * High-risk according to either 1) clinical criteria: TNM (AJCC8) stage III or 2) genetic criteria: monosomy 3 or GEP class 2. Prior to enrolment of the first patient, each site will declare which of the two genetic criteria it uses. Patients with stage I and stage II are only eligible if they meet the genetic criterion declared by the site. * ECOG performance status of 0 or 1 * 18 years or older * HLA-A\*02:01 positivity by local assessment * No evidence of UM recurrence, as evidenced by the required baseline imaging performed within 4 weeks prior to randomization * Adequate organ function * Time-interval between the end of primary treatment and the randomization less than or equal to 12 weeks * Evidence of post-menopausal status or negative urinary or serum pregnancy test for women of childbearing potential (WOCBP) within 3 days prior to randomization. * For patients of childbearing / reproductive potential, agreement to use adequate birth control measures during the study treatment period and for at least 6 months after the last dose of treatment. A highly effective method of birth control is defined as a method which results in a low failure rate (i.e., less than 1% per year) when used consistently and cor…