UnknownPhase 4

Del Nido Versus HTK Cardioplegia in Adult Aortic Valve Replacement

Poland100 participantsStarted 2018-10-01

Plain-language summary

The goal of this clinical trial is to compare del Nido and Bretschneider-HTK (HTK) cardioplegia solutions in patients undergoing elective aortic valve replacement. The main question it aims to answer is: • Does the del Nido cardioplegia provide better cardioprotection and clinical outcomes than HTK cardioplegia? Participants will receive one of the investigated cardioplegia solutions according to the randomization. Researchers will compare both groups in terms of cardioprotection (described as levels of CK-MB and hsTnI), in-hospital clinical outcomes, biochemical changes in coronary sinus blood and one-year follow-up.

Who can participate

Age range18 Years

SexALL

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Inclusion Criteria: * patients aged 18 and over, * qualified for elective isolated aortic valve replacement (AVR) Exclusion Criteria: * patients with significant coronary artery disease, * urgent cases, * cases with additional cardiac procedures.

What they're measuring

postoperative CK-MB

Timeframe: measured in the 6th, 24th, and 48th hour postoperatively

postoperative hsTnI

Timeframe: measured in the 6th, 24th, and 48th hour postoperatively

Trial details

NCT IDNCT06235424

SponsorMedical University of Gdansk

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-04-24

View on ClinicalTrials.gov More Aortic Valve Disease trials