Alerting Providers at Patient Hospital Discharge to Consider Prescribing Rivaroxaban to Reduce Ve… (NCT06232551) | Clinical Trial Compass
RecruitingNot Applicable
Alerting Providers at Patient Hospital Discharge to Consider Prescribing Rivaroxaban to Reduce Venous Thromboembolism
United States152,000 participantsStarted 2024-06-01
Plain-language summary
A new algorithm derived from only patient age and components of the complete blood count and basic metabolic panel can identify patients discharged from the hospital who may benefit from a blood thinner (called rivaroxaban) to decrease their risk of blood clots, and for whom the risk of bleeding is minimal.
The purpose of this study is to evaluate the use of a pop-up alert, which will be seen by clinicians when a discharging patient has been identified as being someone for whom the risk of blood clots is high, but for whom bleeding risk is estimated to be low.
The pop-up alert will be enabled in a sequential fashion for each group of hospitals in 1 month blocks. We will look to see if the pop-up alert changes the number of patients who receive rivaroxaban. We will also measure the outcomes of blood clots and bleeding among all discharging patients.
Who can participate
Age range
18 Years – 110 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Discharging clinician must be in one of the following iCentra electronic health record (Cerner, Kansas City, MO) positions:
* Physician, nurse practitioner, or physician assistant hospitalist
* Physician internal medicine
* Physician family medicine
* Patient age ≥ 18 years.
* The encounter must be inpatient.
* A signed hospital discharge order must be present.
* eVTE target population criteria (increased venous thromboembolism risk, low bleeding risk) must be met
Exclusion Criteria:
* Pregnant during encounter
* Discharge order completed by ineligible clinician type
* Exclude all cases where the patient is being actively prescribed and intended to be discharged on the following qualifying anticoagulant medications, regardless of dose form or dosing regimen (i.e., they have an active prescription for one of these medications):
* Apixaban
* Dabigatran
* Dalteparin
* Enoxaparin
* Edoxaban
* Betrixaban
* Fondaparinux
* Rivaroxaban
* Warfarin
* Creatinine clearance \<30 milliliters/minute based on last-available eligible serum creatinine value preceding discharge
* Estimated creatine clearance based on actual body weight (preferred) ((140 - age years) \* measured weight kilograms) / (72.0 \* serum creatine milligrams/deciliter) (\*0.85 if female)) = milliliters/minute
* If measured body weight not available, then based on ideal body weight ((140 - age years) \* ideal body weight kilograms) / (72.0 \* serum creatine milligram…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Primary outcome (implementation)
Timeframe: From discharge to 7 days after discharge
2
Primary clinical efficacy outcome (effectiveness)
Timeframe: From enrollment until 90 days after enrollment
3
Primary clinical safety outcome
Timeframe: From enrollment until 30 days after enrollment