CompletedNot Applicable

PGT-A Evaluates Advanced Sperm Selection in Embryos From High Teratozoospermia Males

Egypt264 participantsStarted 2023-01-01

Plain-language summary

In this study of 264 couples, sperm selection techniques in males with high teratozoospermia index and sperm DNA fragmentation significantly increased fertilization, blastocyst development rates, and maintained comparable embryo euploidy rates through preimplantation genetic testing, suggesting the efficiency of these techniques in improving assisted reproductive outcomes.

Who can participate

Age range18 Years – 60 Years

SexALL

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Inclusion criteria

✓. Males diagnosed with normal and high teratozoospermia index.
✓. Males with Mild to moderate OTA (oligoteratoasthenozoospermia).
✓. Males aged 18-60 years.
✓. Female aged 18-40 years.
✓. Case must have PGT-A for all of her blastocysts.
✓. Normo responder (\> 5 mature oocytes).
✓. Male will have to refrain from ejaculation no less than 1 day but no greater than 3 days prior semen specimen production on day of ICSI.

Exclusion criteria

✕. Leukocytospermia.
✕. Presence of varicocele.
✕. Known genetic abnormality.
✕. Use of sperm or oocyte donors.
✕. Use of gestational carrier.
✕. Presence of any of the endometrial factors that affect embryo implantation such as hydrosalpings, adenomyosis or previous uterine infection.
✕. Any contradictions to undergoing in vitro fertilization or gonadotropin stimulation.

What they're measuring

Fertilization rate

Timeframe: 1 day

Blastocyst development rate

Timeframe: 5-6 days

Euploidy rate

Timeframe: 15 days post ICSI

Aneuploidy rate

Timeframe: 15 days post ICSI

Trial details

NCT IDNCT06231589

SponsorGanin Fertility Center

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-09-01

View on ClinicalTrials.gov More Teratozoospermia trials