CompletedNot Applicable

Clinical Study of Lung Protective Ventilation Strategies and Tumor Microenvironment

China60 participantsStarted 2024-01-25

Plain-language summary

This study will be conducted in the Affiliated Hospital of Nantong University. Sixty colorectal cancer(CRC) patients are randomized into traditional ventilation strategy group (control group) and lung protective ventilation strategy group (experimental group), there were 30 cases in each group. The control group adopted conventional ventilation strategy; the experimental group used lung protective ventilation strategy. 4ml of central venous blood was extracted at 3 time points within 24h, and relevant experimental indexes were determined. Observe the effect of lung protective ventilation strategy on the microenvironment of tumor inflammation and related hematological indexes in patients undergoing colorectal cancer surgery. Follow-up frailty score and quality of recovery score at 1,3,6, and 12 months after surgery (QoR-15 score scale).

Who can participate

Age range

51 Years – 75 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. pathologic diagnosis of Colorectal Cancer
. American society of Aneshesiologists（ASA）physical status classification system Grade Ⅱ-Ⅲ;
. From 51-70 years old with no gender restrictions
. Normal cardiopulmonary function before operation
. Body Mass Index:18-30

Exclusion criteria

. Preoperative anemia (hemoglobin\<10g/dl)
. Patients with preoperative mechanical ventilation;

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Microenvironment-related indicators of tumor inflammation

Timeframe: 10 minutes before anesthesia, 1 hour and 24 hours after the procedure

Microenvironment-related indicators of tumor inflammation

Timeframe: 10 minutes before anesthesia, 1 hour and 24 hours after the procedure

Microenvironment-related indicators of tumor inflammation

Timeframe: 10 minutes before anesthesia, 1 hour and 24 hours after the procedure

Microenvironment-related indicators of tumor inflammation

Timeframe: 10 minutes before anesthesia, 1 hour and 24 hours after the procedure

Microenvironment-related indicators of tumor inflammation

Timeframe: 10 minutes before anesthesia, 1 hour and 24 hours after the procedure

Microenvironment-related indicators of tumor inflammation

Timeframe: 10 minutes before anesthesia, 1 hour and 24 hours after the procedure

Trial details

NCT IDNCT06230965

SponsorAffiliated Hospital of Nantong University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-02-01

View on ClinicalTrials.gov More Tumor Microenvironment trials

Plain-language summary

Who can participate

Age range

51 Years – 75 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. pathologic diagnosis of Colorectal Cancer
. American society of Aneshesiologists（ASA）physical status classification system Grade Ⅱ-Ⅲ;
. From 51-70 years old with no gender restrictions
. Normal cardiopulmonary function before operation
. Body Mass Index:18-30

Exclusion criteria

. Preoperative anemia (hemoglobin\<10g/dl)
. Patients with preoperative mechanical ventilation;

What they're measuring

Microenvironment-related indicators of tumor inflammation

Timeframe: 10 minutes before anesthesia, 1 hour and 24 hours after the procedure

Microenvironment-related indicators of tumor inflammation

Timeframe: 10 minutes before anesthesia, 1 hour and 24 hours after the procedure

Microenvironment-related indicators of tumor inflammation

Timeframe: 10 minutes before anesthesia, 1 hour and 24 hours after the procedure

Microenvironment-related indicators of tumor inflammation

Timeframe: 10 minutes before anesthesia, 1 hour and 24 hours after the procedure

Microenvironment-related indicators of tumor inflammation

Timeframe: 10 minutes before anesthesia, 1 hour and 24 hours after the procedure

Microenvironment-related indicators of tumor inflammation

Timeframe: 10 minutes before anesthesia, 1 hour and 24 hours after the procedure