CompletedNot Applicable

Clinical Study of Lung Protective Ventilation Strategies and Tumor Microenvironment

China60 participantsStarted 2024-01-25

Plain-language summary

This study will be conducted in the Affiliated Hospital of Nantong University. Sixty colorectal cancer(CRC) patients are randomized into traditional ventilation strategy group (control group) and lung protective ventilation strategy group (experimental group), there were 30 cases in each group. The control group adopted conventional ventilation strategy; the experimental group used lung protective ventilation strategy. 4ml of central venous blood was extracted at 3 time points within 24h, and relevant experimental indexes were determined. Observe the effect of lung protective ventilation strategy on the microenvironment of tumor inflammation and related hematological indexes in patients undergoing colorectal cancer surgery. Follow-up frailty score and quality of recovery score at 1,3,6, and 12 months after surgery (QoR-15 score scale).

Who can participate

Age range51 Years – 75 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. pathologic diagnosis of Colorectal Cancer
✓. American society of Aneshesiologists（ASA）physical status classification system Grade Ⅱ-Ⅲ;
✓. From 51-70 years old with no gender restrictions
✓. Normal cardiopulmonary function before operation
✓. Body Mass Index:18-30

Exclusion criteria

✕. Preoperative anemia (hemoglobin\<10g/dl)
✕. Patients with preoperative mechanical ventilation;
✕. A history of pulmonary infection and pulmonary tuberculosis within 1 month before surgery;
✕. Preoperative blood oxygen saturation (SpO₂) was less than 90% (SpO₂\<90%), or the oxygen partial pressure (PaO₂) was less than 90% (PaO₂\<60 mmHg), or PaO₂/fraction of inspired oxygen（FiO₂）ratio\<300 mmHg, or arterial blood carbon dioxide partial pressure (PaCO₂) was greater than 45 mmHg (PaCO₂\>45 mmHg);

What they're measuring

Microenvironment-related indicators of tumor inflammation

Timeframe: 10 minutes before anesthesia, 1 hour and 24 hours after the procedure

Microenvironment-related indicators of tumor inflammation

Timeframe: 10 minutes before anesthesia, 1 hour and 24 hours after the procedure

Microenvironment-related indicators of tumor inflammation

Timeframe: 10 minutes before anesthesia, 1 hour and 24 hours after the procedure

Microenvironment-related indicators of tumor inflammation

Timeframe: 10 minutes before anesthesia, 1 hour and 24 hours after the procedure

Microenvironment-related indicators of tumor inflammation

Timeframe: 10 minutes before anesthesia, 1 hour and 24 hours after the procedure

Microenvironment-related indicators of tumor inflammation

Timeframe: 10 minutes before anesthesia, 1 hour and 24 hours after the procedure

Microenvironment-related indicators of tumor inflammation

Timeframe: 10 minutes before anesthesia, 1 hour and 24 hours after the procedure

Trial details

NCT IDNCT06230965

SponsorAffiliated Hospital of Nantong University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-02-01

View on ClinicalTrials.gov More Tumor Microenvironment trials

Plain-language summary

Who can participate

Age range51 Years – 75 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. pathologic diagnosis of Colorectal Cancer
✓. American society of Aneshesiologists（ASA）physical status classification system Grade Ⅱ-Ⅲ;
✓. From 51-70 years old with no gender restrictions
✓. Normal cardiopulmonary function before operation
✓. Body Mass Index:18-30

Exclusion criteria

✕. Preoperative anemia (hemoglobin\<10g/dl)
✕. Patients with preoperative mechanical ventilation;
✕. A history of pulmonary infection and pulmonary tuberculosis within 1 month before surgery;
✕. Preoperative blood oxygen saturation (SpO₂) was less than 90% (SpO₂\<90%), or the oxygen partial pressure (PaO₂) was less than 90% (PaO₂\<60 mmHg), or PaO₂/fraction of inspired oxygen（FiO₂）ratio\<300 mmHg, or arterial blood carbon dioxide partial pressure (PaCO₂) was greater than 45 mmHg (PaCO₂\>45 mmHg);

What they're measuring

Microenvironment-related indicators of tumor inflammation

Timeframe: 10 minutes before anesthesia, 1 hour and 24 hours after the procedure

Microenvironment-related indicators of tumor inflammation

Timeframe: 10 minutes before anesthesia, 1 hour and 24 hours after the procedure

Microenvironment-related indicators of tumor inflammation

Timeframe: 10 minutes before anesthesia, 1 hour and 24 hours after the procedure

Microenvironment-related indicators of tumor inflammation

Timeframe: 10 minutes before anesthesia, 1 hour and 24 hours after the procedure

Microenvironment-related indicators of tumor inflammation

Timeframe: 10 minutes before anesthesia, 1 hour and 24 hours after the procedure

Microenvironment-related indicators of tumor inflammation

Timeframe: 10 minutes before anesthesia, 1 hour and 24 hours after the procedure

Microenvironment-related indicators of tumor inflammation

Timeframe: 10 minutes before anesthesia, 1 hour and 24 hours after the procedure