RecruitingNot Applicable

Comparison of Catecholamine Concentrations in Venous Blood During Selective Adrenal Artery Embolization

China196 participantsStarted 2023-09-18

Plain-language summary

To explore the relationship between perioperative blood pressure and catecholamine concentrations in adrenal venous blood and peripheral venous blood in hypertensive patients with primary aldosteronism (PA) who underwent percutaneous selective adrenal artery embolization (SAAE). In order to elucidate the related phenomena and possible mechanisms of blood pressure fluctuations caused by SAAE treatment in hypertensive patients with PA.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Age ≥18 years with no gender restrictions.
. Adherence to the "Primary Aldosteronism" Diagnosis and Treatment Guidelines, confirmed diagnosis of primary aldosteronism following rigorous drug washout, and identification as either aldosteronoma or idiopathic aldosteronism via adrenal vein blood sampling.
. Blood pressure metrics that satisfy any of the subsequent conditions: a) Clinic-recorded blood pressure ≥140/90mmHg; b) 24-hour ambulatory blood pressure monitoring results displaying average blood pressure \>130/80 mmHg or daytime readings \>135/85 mmHg.
. Adrenal CT scan revealing adrenal hyperplasia, nodular formations, or no significant morphological deviations.
. Hypertension history surpassing a duration of 6 months.
. Prior to screening, patients or their lawful guardians must provide a signed informed consent, sanctioned by the ethics committee.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Invasive blood pressure

Timeframe: Selective adrenal artery embolization immediately, after 5 minutes, 15 minutes, 30 minutes

24-hour dynamic blood pressure

Timeframe: Selective adrenal artery embolization before 24 hours, after 24 hours

Plasma Norepinephrine

Timeframe: Selective adrenal artery embolization immediately, after 5 minutes, 15 minutes, 30 minutes

Plasma Adrenaline

Timeframe: Selective adrenal artery embolization immediately, after 5 minutes, 15 minutes, 30 minutes

Plasma Dopamin

Timeframe: Selective adrenal artery embolization immediately, after 5 minutes, 15 minutes, 30 minutes

Plasma Renin

Timeframe: Selective adrenal artery embolization immediately, after 5 minutes, 15 minutes, 30 minutes

Plasma Aldosterone

Timeframe: Selective adrenal artery embolization immediately, after 5 minutes, 15 minutes, 30 minutes

Trial details

NCT IDNCT06228677

SponsorFirst Affiliated Hospital of Chengdu Medical College

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-06-30

Contact for this trial

Peijian Wang, PhD

028-83016145 wpjmed@aliyun.com

View on ClinicalTrials.gov More Resistant Hypertension trials

Plain-language summary

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Age ≥18 years with no gender restrictions.
. Adherence to the "Primary Aldosteronism" Diagnosis and Treatment Guidelines, confirmed diagnosis of primary aldosteronism following rigorous drug washout, and identification as either aldosteronoma or idiopathic aldosteronism via adrenal vein blood sampling.
. Blood pressure metrics that satisfy any of the subsequent conditions: a) Clinic-recorded blood pressure ≥140/90mmHg; b) 24-hour ambulatory blood pressure monitoring results displaying average blood pressure \>130/80 mmHg or daytime readings \>135/85 mmHg.
. Adrenal CT scan revealing adrenal hyperplasia, nodular formations, or no significant morphological deviations.
. Hypertension history surpassing a duration of 6 months.
. Prior to screening, patients or their lawful guardians must provide a signed informed consent, sanctioned by the ethics committee.

What they're measuring

Invasive blood pressure

Timeframe: Selective adrenal artery embolization immediately, after 5 minutes, 15 minutes, 30 minutes

24-hour dynamic blood pressure

Timeframe: Selective adrenal artery embolization before 24 hours, after 24 hours

Plasma Norepinephrine

Timeframe: Selective adrenal artery embolization immediately, after 5 minutes, 15 minutes, 30 minutes

Plasma Adrenaline

Timeframe: Selective adrenal artery embolization immediately, after 5 minutes, 15 minutes, 30 minutes

Plasma Dopamin

Timeframe: Selective adrenal artery embolization immediately, after 5 minutes, 15 minutes, 30 minutes

Plasma Renin

Timeframe: Selective adrenal artery embolization immediately, after 5 minutes, 15 minutes, 30 minutes

Plasma Aldosterone

Timeframe: Selective adrenal artery embolization immediately, after 5 minutes, 15 minutes, 30 minutes

Comparison of Catecholamine Concentrations in Venous Blood During Selective Adrenal Artery Embolization

Plain-language summary

Who can participate

Inclusion criteria

Questions worth asking your doctor

Questions for the trial coordinator

What they're measuring

Trial details

Contact for this trial

Comparison of Catecholamine Concentrations in Venous Blood During Selective Adrenal Artery Embolization

Plain-language summary

Who can participate

Inclusion criteria

Questions worth asking your doctor

Questions for the trial coordinator

What they're measuring

Trial details

Contact for this trial

Exclusion criteria