Molecular Imaging in Fabry Disease of the Heart

Inclusion Criteria: * Male or female participants \>18 years old * Able to give written, informed consent and to lie flat * Have Fabry disease based on molecular diagnosis (at a minimum, documented enzyme deficiency in males and documented pathogenic mutation in females) * Cardiac MRI within 3 years documenting cardiac involvement in Fabry disease (left ventricular hypertrophy and/or late gadolinium enhancement and/or myocardial oedema) Exclusion Criteria: * Any other diagnosis associated with cardiac muscle inflammation, including myocarditis * Previous gene therapy * Contra-indication to MRI scanning or intravenous gadolinium contrast (prior contrast reaction or chronic kidney disease with eGFR \<30 mL/min/1.73 m2) * Women of child bearing potential not using adequate contraception * Uncontrolled atrial fibrillation * Any medical condition, in the opinion of the investigator, that prevents the participant from lying flat during scanning, or from participating in the study