Vitamin C Deficiency in Septic Shock (NCT06224881) | Clinical Trial Compass
CompletedPhase 4
Vitamin C Deficiency in Septic Shock
Egypt150 participantsStarted 2021-12-01
Plain-language summary
Objectives: investigators aim to study the effect of addition of vitamin C as a part of treatment in septic shock patients on: Hemodynamics, Inflammation status and ICU outcome.
Subjects and methods: A prospective interventional randomized cohort study, was conducted on 150 consecutive patients who were admitted to the ICU with septic shock based on SIRS, SOFA and APACHE II. Treatment group (n=75) had given ascorbic acid (Vitamin C) parenterally 6gm daily and control group (n=75). Measuring the level of Vitamin C in all study population (normal range 50-70 μM/L) before and after period of 4 days.
Who can participate
Age range
18 Years – 80 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Septic shock (defined by sepsis induced hypotension i.e. MAP \< 65 mmHg, tissue hypo-perfusion, vasopressors
Exclusion Criteria:
* Age below 18 years old
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Since this trial specifically looked at vitamin C deficiency in septic shock patients, is it worth testing my vitamin C levels as part of my current care, and could deficiency be playing a role in my condition?
2This was a Phase 4 trial, which means vitamin C has already been through earlier safety testing — so what does my doctor think the completed results of this study suggest about using vitamin C alongside standard septic shock treatment?
3The trial measured C-reactive protein as a primary outcome, which is a marker of inflammation — based on my own CRP levels, does my doctor think the findings from this study are relevant to my situation?
4Mean arterial blood pressure was one of the key things being tracked in this trial — given that blood pressure stability is central to septic shock management, how does my doctor currently plan to manage mine, and does vitamin C fit into that picture?
5Since this trial has already been completed, has my doctor seen any of its results or findings that might influence whether they'd consider vitamin C as part of my treatment plan?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.