CompletedNot Applicable

Respiratory Drive and Inspiratory Effort in COVID-19 Associated ARDS

Italy56 participantsStarted 2020-11-21

Plain-language summary

Data comparing respiratory drive and effort in critically ill patients with acute respiratory distress syndrome associated to different severity of COVID-19 penumonia (CARDS) and to other risk factors are lacking. Objectives: To assess respiratory drive and effort of CARDS patients at the first transition from controlled to assisted spontaneous breathing. The second aim was the rate of a composite outcome including the need of higher level of sedation

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. Improvement of the condition leading to acute respiratory failure.
✓. Positive end-expiratory pressure lower than 10 cmH2O and inspiratory oxygen fraction lower than 0.5.
✓. Richmond agitation sedation scale score between 0 and -3.
✓. Ability to trigger the ventilator, i.e., decrease pressure airway opening by more than 3-4 cmH2O during a brief (5-10 seconds) end-expiratory occlusion test.

What they're measuring

Respiratory drive

Timeframe: 90 breaths

Neuroventilatory coupling

Timeframe: 90 breaths

Respiratory effort

Timeframe: 90 breaths

Transpulmonary driving pressure

Timeframe: 90 breaths

Trial details

NCT IDNCT06224010

SponsorUniversity of Turin, Italy

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2023-06-01

View on ClinicalTrials.gov More ARDS, Human trials