The Role of Pharmaco-mechanical Thrombectomy in Management of Acute Lower Extremity Arterial Ischemia

Inclusion Criteria: * Age ≥ 18 years * Symptom onset within 14 days for acute limb ischemia or within 30 days for subacute limb ischemia due to embolic or thrombotic occlusion of a native arteries, bypass graft, or arterial stent. Rutherford category I, IIa or IIb Exclusion Criteria: * ALLI secondary to dissections, vasculitis, and/or target vessel trauma * Pregnancy or positive pregnancy test * Rutherford category III Irreversible (neglected) limb ischemia * patients allergic to contrast agent, * serum creatine\>300 mmol/L