Stem Cell Derived Exosomes in the Treatment of Melasma and Its Percutaneous Penetration

Exclusion criteria

• ✕. Patients who refuse to sign the informed consent form to participate in the trial;
• ✕. Those with a history of important organ diseases, or a history of autoimmune diseases or immune dysfunction;
• ✕. Abnormal coagulation function, current use of anticoagulants, thrombophilia and history of familial genetic diseases;
• ✕. Pregnant or lactating women;
• ✕. Patients taking oral contraceptives or hormone replacement therapy during the study period or within the past 12 months;
• ✕. Patients with scar constitution;
• ✕. Active skin infection;
• ✕. Those who have a history of multiple severe allergies, a history of hereditary allergies, photosensitivity or photosensitivity drugs, such as sulfa drugs and tetracyclines, those who are allergic to local anesthetics and those who are allergic to lidocaine components, and those who plan to undergo detoxification during the study Allergy healer;