The investigators initial study opened the way for randomized trials that monitor the effects of acetylcholine (Ach) iontophoresis vasodilators on endothelial nitric oxide synthetase (NOS) to develop a transdermal treatment that is effective, free from systemic adverse effects.
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Role of acetylcholine iontophoresis in improving Nitric oxide level in diabetic peripheral neuropathy patients.
Timeframe: one month (baseline assessment and after one month of Ach iontophoresis and exercise)
Electrophysiological assessment of patients with acetylcholine iontophoresis and Ach iontophoresis role in improving diabetic peripheral neuropathy
Timeframe: one month (baseline assessment and after one month of Ach iontophoresis and exercise)
Numerical rating pain scale
Timeframe: One month