RecruitingPhase 1/2

Effect of Honey For CIN II

Netherlands60 participantsStarted 2024-12-30

Plain-language summary

The following hypothesis is tested: Medical grade honey in CIN II causes a higher clearance of the hr-HPV virus and an increase in the normalization of CIN II lesions compared to expectant management.

Who can participate

Age range

18 Years – 40 Years

Sex

FEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Women 18-40 years * Primary CIN II confirmed histologically in the biopsy on colposcopic examination * Sufficient mastery of the Dutch language Exclusion Criteria: * Simultaneous abnormality in columnar epithelial cells (AIS). * Hr-HPV negative cytology * Immunosuppressant use/Autoimmune disease (HIV, CVID) * History of cervical carcinoma or previous treatment for CIN (LLETZ or imiquimod) * Pregnancy or the intention to become pregnant during the study period * Legal incompetence * Known allergies to honey

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Clearance of hr-HPV

Timeframe: 6 months

Trial details

NCT IDNCT06219018

SponsorZuyderland Medisch Centrum

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-12-01

Contact for this trial

Jordy Mongula, dr.

+31621872080 j.mongula@zuyderland.nl

View on ClinicalTrials.gov More Cervical Intraepithelial Neoplasia-II trials