Optimization and Harmonization of Advanced MRI Sequences

Inclusion Criteria: for patients * accident cases * time of onset of NOT MORE THAN 24 months * Clinical Dementia Rating Scale (CDR) \<=2; * MoCA\<=17 for controls absence of complaints of cognitive disorders and/or neurological/neuropsychological visits for the evaluation of such disorders; * CDR = 0; * MoCA\>=27. for all Age \>= 50 and \<= 80; * Hachinski Ischemic Scale - 7 items \< 2; * visual and/or auditory acuity sufficient to carry out the neuropsychological assessment; * if on neuropsychopharmacological therapy, stability for 4 weeks before the start of the study. Exclusion Criteria: for all * any uncontrolled medical condition or neurological/neurodegenerative disease that, in the opinion of the recruiting physician, could contribute to the individual's cognitive impairment \[e.g., kidney disease, liver disease, brain tumor, alcohol or drug abuse, abnormal thyroid function, hydrocephalus normotensive, vascular dementia, neurocognitive disorder due to head trauma (according to the diagnostic criteria of the DSM V)\]; * transient ischemic attack or stroke during the 12 months preceding screening; history of unstable angina, myocardial infarction, heart failure (New York Heart Association Class III or IV), or clinically significant heart rhythm disturbances documented within one year of screening; * history of malignant tumor disease, except: cancer in remission for more than 5 years since screening; prostate cancer in situ; * history of surgically treated squamou…