CompletedPhase 4

Staph Intervention for Effective Local Defense

United States78 participantsStarted 2024-04-01

Plain-language summary

Indigenous persons experience a high burden of Staphylococcus aureus (SA) invasive disease and skin and soft tissue infections. SA carriage on the skin is factor for development of SA infections. The goal of this clinical trial is to evaluate a community-informed approach to reduce carriage of SA. Participants will be assigned to education and household supplies for prevention of SA with and without a biomedical intervention. Researchers will compare SA carriage in the two groups.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Native American adult living on or adjacent to the WMA Tribal lands * 18 years of age and older * Lab-confirmed SA carriage at time of enrollment * Ability to provide written informed consent * Ability to comply with follow-up activities * Risk factor for SA-associated infection: Diagnosed with diabetes OR body mass index ≥30 OR documented SSTI or SA infection in the past 3 years Exclusion Criteria: * Immediate family member of study staff * Allergy to citrus or any ingredient in Nozin, Hibiclens, or mupirocin * Without a permanent home (e.g., living in a group home, shelter, or is unhoused) * Use of antibiotics within 30 days prior to the first study visit (time-limited) * Current SA infection (time-limited)

What they're measuring

Prevalence of SA carriage

Timeframe: 4 months after randomization

Trial details

NCT IDNCT06210594

SponsorJohns Hopkins Bloomberg School of Public Health

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-11-14

View on ClinicalTrials.gov More Staphylococcus Aureus Infection trials