By InvitationNot Applicable

The Involvement of the Gut Hormone GIP in the Pathophysiology of Post Prandial Hypotension

Denmark18 participantsStarted 2024-05-15

Plain-language summary

The present study investigates the involvement of the gut hormone glucose-dependent insulinotropic polypeptide (GIP) in the pathophysiology of postprandial hypotension (PPH)

Who can participate

Age range18 Years – 85 Years

SexALL

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Inclusion criteria

✓. Age 18-85 years
✓. History of PPH-related symptoms like dizziness, lightheadedness, palpitations, or fainting after meal ingestion
✓. Informed consent

Exclusion criteria

✕. Not fulfilling the PPH diagnosis during the mixed meal test or during the test meal with increased (+25%) number of calories
✕. Treatment with antihypertensives
✕. Treatment with SNRI (Serotonin and Noradrenalin Reuptake Inhibitor) or treatment within three months before screening visit
✕. Allergy or intolerance to ingredients included in the mixed meal
✕. Any ongoing medication that the investigator evaluates would interfere with trial participation
✕. Any physical or psychological condition that the investigator evaluates would interfere with trial participation, including any acute or chronic illnesses
✕. Anaemia (haemoglobin below normal range \<7.3 mmol/L for women and \<8.3 mmol/L for men)
✕. Moderate to severe loss of kidney function (estimated glomerular filtration rate (eGFR) \<45 ml/min/1.73 m2) at screening

What they're measuring

Nadir systolic blood pressure (SBP) (mmHg)

Timeframe: -45-0 minutes

Nadir systolic blood pressure (mmHg)

Timeframe: 0-180 minutes

Trial details

NCT IDNCT06208904

SponsorUniversity Hospital, Gentofte, Copenhagen

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-12-31

View on ClinicalTrials.gov More PostPrandial Hypotension trials