Active — Not RecruitingNot Applicable

Perceptions of E-Cigarettes and Synthetic Cooling Agents, The ICE Study

United States158 participantsStarted 2024-05-08

Plain-language summary

This study evaluates how synthetic cooling additives like WS-3 and WS-23 impact e-cigarette perceptions, use behavior, and toxicant exposure.

Who can participate

Age range

21 Years – 29 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Aged 21-29 years * Current e-cigarette (EC) user (defined as ≥ weekly use over the past 3 months) * Willing to provide informed consent and abstain from using their EC at least 12 hours prior to the four lab sessions * Read and speak English Exclusion Criteria: * Recently COVID-19+ (defined as positive test in the past 30 days) or a recent COVID-19 hospitalization (defined as a hospitalization within the past 6 months) * Unstable or significant psychiatric conditions (past and stable conditions will be allowed) * History of cardiac event or distress within the past 3 months * Are currently pregnant, planning to become pregnant, or breastfeeding (will be verified with urine pregnancy test) * Have suffered from any serious lung disease or infection (e.g. , tuberculosis, cystic fibrosis, or lung cancer) in the past 30 days * Have hemophilia or another type of bleeding disorder * Are blind, severely visually impaired, deaf, hard of hearing, or have a severe motor disability

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Satisfaction and psychological reward

Timeframe: Minute 5 of vaping session, Minute 35 of vaping session

Sensory perceptions of EC vaping experience

Timeframe: Pre-vaping session

E-cigarette puff topography

Timeframe: 35 Minute Vaping session

Levels of HPHC and other toxicant exposure from vaping e-liquids

Timeframe: After completion of sessions, estimated 4 years

Appeal and Sensory

Timeframe: Minute 5 of vaping session, Minute 35 of vaping session

Trial details

NCT IDNCT06208202

SponsorOhio State University Comprehensive Cancer Center

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-12

View on ClinicalTrials.gov More Abuse Tobacco trials

Who can participate

Age range

21 Years – 29 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Satisfaction and psychological reward

Timeframe: Minute 5 of vaping session, Minute 35 of vaping session

Sensory perceptions of EC vaping experience

Timeframe: Pre-vaping session

E-cigarette puff topography

Timeframe: 35 Minute Vaping session

Levels of HPHC and other toxicant exposure from vaping e-liquids

Timeframe: After completion of sessions, estimated 4 years

Appeal and Sensory

Timeframe: Minute 5 of vaping session, Minute 35 of vaping session