UnknownNot Applicable

The Anesthesia Effects of Dexmedetomidine Combined With Desflurane or Propofol in Lobectomy

China120 participantsStarted 2023-10-21

Plain-language summary

In one-lung ventilation surgery, compared with dexmedetomidine combined with propofol, dexmedetomidine combined with desflurane may be beneficial to accelerate patients' recovery and reduce postoperative pulmonary complications and does not increase the incidences of delirium and postoperative nausea and vomiting.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Patients undergoing elective thoracoscopic unilateral lobectomy.
✓. General anesthesia is required and the expected duration of one-lung ventilation is ≥ 1h.
✓. American Association of Anesthesiologists (ASA) physical condition classification I-III.
✓. Patients over 18 years old.
✓. Voluntary participation and ability to understand and sign the informed consent.

Exclusion criteria

✕. Obese patients (BMI\>28 kg/m2).
✕. patients with grade 3 hypertension (systolic blood pressure ≥180 mmHg and/or diastolic blood pressure ≥110 mmHg).
✕. Acute coronary syndrome, sinus bradycardia (heart rate \< 45 beats/min), II or III degree atrioventricular block, NYHA heart function classification III or IV.
✕. Patients with severe history of chronic obstructive pulmonary disease (GOLD grade III or IV of pulmonary function of chronic obstructive pulmonary disease), severe or uncontrolled bronchial asthma, pulmonary infection, bronchiectasis and thoracic deformity.
✕. Pulmonary artery pressure ≥60 mmHg.
✕. Patients with Child grade B or C of liver function.
✕. Patients with chronic kidney disease in stage 4 or 5.

What they're measuring

Time to open eyes after anesthetics withdrawal

Timeframe: From time of anesthetic withdrawal to the first time of the patient open his or her eyes, assessed up to 2 hour.

Trial details

NCT IDNCT06207344

SponsorThe Second Affiliated Hospital of Chongqing Medical University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-12-30

Contact for this trial

Yu Chen

8602362887913 cypgxhcj@tom.com

View on ClinicalTrials.gov More Anesthesia Recovery Period trials