Prehabilitative Exercise Prior to Immobilization (NCT06205784) | Clinical Trial Compass
CompletedNot Applicable
Prehabilitative Exercise Prior to Immobilization
Denmark64 participantsStarted 2024-01-06
Plain-language summary
This is a 10-week human study involving 24 younger (20-35 y) and 24 older (65-85 y) healthy individuals. All participants will undergo unilateral immobilization of a knee for 7-10 days, followed by 4 weeks of heavy resistance exercise training (HReT). Half of the participants (12 younger and 12 older) will also undergo 4 weeks HReT prior to the immobilization. Prehabilitative exercise may confer protective effects on subsequent immobilization, and the various underlying mechanisms involved
Who can participate
Age range
20 Years – 85 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age: Between 20-35 years old or between 65-85 years old.
* BMI: Between 18.5 and 35 kg/m2.
* Healthy and well, with normal dietary habits (not vegan).
Exclusion Criteria:
* More than one muscle biopsy previously taken from both vastus lateralis muscles.
* Smoking.
* Pregnancy.
* Past or present substance or alcohol abuse.
* Medical/surgical conditions that are assessed to affect protein synthesis or the participant's involvement in the trial.
* Knee pain that could affect the completion of the training intervention.
* High intake of supplements that increase the risk of bleeding during muscle biopsy (such as fish oil and ginger).
* Participation in regular strength training within the past year.
* Regular participation in structured sports.
* Current use of blood-thinning medication.
* Previous participation in trials involving oral intake of heavy water.
* Metal in the body preventing MRI scanning.
* For the older group, not having gone through menopause, and for the younger group, not having a regular menstrual cycle.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Quadriceps cross-sectional area
Timeframe: From pre (week 0) to post immobilization (week 5)