Analgesic Effect of Ropivacaine Combined With Hydromorphone for CSEA After Total Knee Arthroplasty (NCT06205199) | Clinical Trial Compass
CompletedNot Applicable
Analgesic Effect of Ropivacaine Combined With Hydromorphone for CSEA After Total Knee Arthroplasty
China136 participantsStarted 2022-10-27
Plain-language summary
The aim of this study is to investigate the continuous analgesic effect and side effects of ropivacaine combined with hydromorphone for combined spinal-epidural anesthesia(CSEA) after total knee arthroplasty and to explore its clinical application value. To observe whether hydromorphone combined with ropivacaine can promote the rapid recovery of patients.
Who can participate
Age range
55 Years – 80 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age between 55 and 80 years old.
* ASA grade I to III.
* BMI:20-29kg/m2.
* No recent use of sedatives, opioids, or other analgesics.
* There was no contraindication of spinal anesthesia, severe dysfunction of heart, lung and other important organs or serious systemic diseases.
* Patients were willing to participate in the study and signed the informed consent.
Exclusion Criteria:
* The patient has mental illness or cannot cooperate with the completion of spinal anesthesia.
* The patient had a history of spinal surgery and spinal deformity.
* Patients had a history of opioid intolerance or adverse reactions.
* puncture site infection, coagulopathy or recent use of anticoagulant drugs.
* History of allergy to local anesthetics.
* Failed puncture.
* Unable to cooperate to complete the research process.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Incidence of moderate to severe pain at rest at 6, 12, 18, and 24 hours after anesthesia.
Timeframe: 6, 12, 18, and 24 hours after anesthesia
2
Incidence of moderate to severe pain with movement at 6, 12, 18, and 24 hours after anesthesia.
Timeframe: 6, 12, 18, and 24 hours after anesthesia