CompletedNot Applicable

Effect of Irrigation-Activation Techniques on Healing in Large Periapical Lesions

Turkey (Türkiye)97 participantsStarted 2021-11-01

Plain-language summary

The aim of this study was to highlight the healing rates of large periapical lesions after different irrigation activation treatments as manual dynamic activation (MDA), passive ultrasonic irrigation (PUI), shock wave-enhanced emission photoacoustic streaming (SWEEPS) using CBCT scans based on volumetric change analysis during 1-year follow-up.

Who can participate

Age range

18 Years – 65 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients having single root mandibular teeth * Patients the diagnosis of chronic apical periodontitis, * Periapical index score of 3 and above, * Patients having good oral hygiene Exclusion Criteria: * Patients with systemic diseases (diabetes, hypertension, chronic liver disease, coagulation disorders), * Patients with bone metabolism disease and/or * Patients using drugs that affect bone metabolism (such as steroids, bisphosphonates) * Patients with a history of radiotherapy * Pregnant patients * Teeth with mobility of 2 or more, periodontal pocket depth of 5 mm or more, generalized chronic periodontitis, internal and external resorption, and/or vertical and horizontal root fractures

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Percentage Change in Lesion Volume at 12-months Follow-up

Timeframe: One year from the beginning of the study

Distribution of Lesion Status in Different Irrigation Groups at 12-year Follow-up

Timeframe: One year from the beginning of the study

Trial details

NCT IDNCT06204887

SponsorRecep Tayyip Erdogan University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-02-27

Results submitted2024-05-17

View on ClinicalTrials.gov More Effect of Irrigation Activation on Periapical Healing trials