Effect of Irrigation-Activation Techniques on Healing in Large Periapical Lesions

Inclusion Criteria: * Patients having single root mandibular teeth * Patients the diagnosis of chronic apical periodontitis, * Periapical index score of 3 and above, * Patients having good oral hygiene Exclusion Criteria: * Patients with systemic diseases (diabetes, hypertension, chronic liver disease, coagulation disorders), * Patients with bone metabolism disease and/or * Patients using drugs that affect bone metabolism (such as steroids, bisphosphonates) * Patients with a history of radiotherapy * Pregnant patients * Teeth with mobility of 2 or more, periodontal pocket depth of 5 mm or more, generalized chronic periodontitis, internal and external resorption, and/or vertical and horizontal root fractures