The Effect of Prehospital Combination of Epinephrine, Vasopressin, and Steroid in OHCA (NCT06203847) | Clinical Trial Compass
RecruitingNot Applicable
The Effect of Prehospital Combination of Epinephrine, Vasopressin, and Steroid in OHCA
Taiwan1,344 participantsStarted 2024-07-16
Plain-language summary
This project is a randomized controlled clinical research design, The hypothesis P-I-C-O of the study is: For adult patients in the Taipei City and New Taipei City communities who have suffered sudden non-traumatic death and have been resuscitated by advanced paramedics, the intervention group that receives combined drug treatment (epinephrine, vasopressin, methylprednisolone) has a better rate of sustained recovery of spontaneous circulation (ROSC) (primary outcome) and long-term survival status (secondary outcomes) compared to the control group that receives single drug treatment (epinephrine).
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adult patients (aged \>= 18 )
* Out-of-hospital cardiac arrest in the studied regions
* Treated by paramedics authorized and capable of giving prehospital medication
Exclusion Criteria:
* OHCA with traumatic etiology
* Obvious signs of death like decapitation, rigor mortis, livor mortis, decomposition, etc.
* DNR (Do Not Resuscitation) or termination of resuscitation requested by the family
* Patients with known or suspected pregnancy
* No vascular access was established before hospital arrival
* ROSC before the administrated medication
* No patient contact (cancelled ambulance call or the patient was transported to the hospital before the arrival of trial-trained paramedics)
* Received epinephrine prior to the arrival of trial-trained paramedics
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Rate of sustained return of spontaneous circulation (ROSC)