Platelet-rich Fibrin(PRF) Membrane in Ophthalmic Diseases
China170 participantsStarted 2023-01-01
Plain-language summary
The goal of this clinical trial is to observe the role of PRF in treating ophthalmic diseases.The efficacy and safety of PRF were validated for four ophthalmic conditions: macular hole, pterygium, corneal ulcer, and patients undergoing trabeculectomy for glaucoma. The main question aims to answer is PRF's effectiveness in ocular surface and fundus diseases. Participants will be divided into 2 groups, the experimental group will be treated with PRF and the control group will be treated with conventional surgery, with a 12-month postoperative follow-up to determine the role of PRF on wound healing in ophthalmic diseases.
Who can participate
Age range
20 Years – 90 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Diagnosis of macular hole confirmed by fundus examination;
. Diagnosis of pterygium by slit lamp;
. Patients requiring trabeculectomy for glaucoma;
. Diagnosis of corneal ulcer confirmed by slit lamp.
Exclusion criteria
. Combination of other active ophthalmic diseases, such as acute conjunctivitis and uveitis;
. Previous history of ophthalmic trauma and ophthalmic surgery;
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Whether the macular hole is closed in participants with macular hole(Unit: yes/no)
Timeframe: Pre-operation, and at 1 week, 1 month, 3 months, and 6 months post-operation.
2
Whether the wound heals completely after pterygium excision in participants with pterygium(Unit: yes/no)
Timeframe: Pre-operation, and at 1 week, 1 month, 3 months, and 6 months post-operation.
3
IOP in participants undergoing trabeculectomy for glaucoma(Unit: mmHg)
Timeframe: Pre-operation, and at 1 week, 1 month, 3 months, and 6 months post-operation.
4
Whether the corneal ulcer is healing in participants with corneal ulcer(Unit: yes/no)
Timeframe: Pre-operation, and at 1 week, 1 month, 3 months, and 6 months post-operation.