Not Yet RecruitingPhase 4

TRAP Study: Testosterone for Androgen Receptor Polymorphism

Spain100 participantsStarted 2025-09-30

Plain-language summary

To determine whether pretreatment with transdermal testosterone increases the number of cumulus-oocyte complexes (COCs) obtained after ovarian stimulation by more than 1.5 in patients with low ovarian reserve and androgen receptor polymorphism undergoing intracytoplasmic sperm injection (ICSI).

Who can participate

Age range18 Years – 40 Years

SexFEMALE

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Inclusion criteria

✓. Age equal to or greater than 40 years.
✓. Previous cycle with less than 4 oocytes retrieved.
✓. Low ovarian reserve markers (antral follicle count \<5-7; AMH \<0.5-1.1 ng).

What they're measuring

Number of COC (cumulus-oocyte complexes)

Timeframe: Egg collection day (between 8 and 14 days after starting of ovarian stimulation)

Trial details

NCT IDNCT06195163

SponsorInstituto Bernabeu

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-09-30

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