Whole Blood Transcriptomic Signal According to Coronary Atherosclerotic Plaque Burden Assessed by CT Angiography

Inclusion Criteria: * Men and women between 18 and 75 years, with a clinical indication to be evaluated by a CCTA due to suspected or known CAD. * Signature of informed consent. Exclusion Criteria: * Previously known chronic renal or hepatic insufficiency. * Active chronic lung disease, defined as: exacerbated asthma, exacerbated COPD, or pulmonary fibrosis. * Myocardial infarction, unstable angina, cerebrovascular accident, or vascular interventions (any territory) in the past 6 months. * Implantation of drug-eluting stents in the last 12 months. * Revascularization surgery (By-pass) * Indication of Angio-CT for congenital heart disease or Transcatheter Aortic Valve Replacement (TAVI) * Presence/ diagnosis of heart failure symptoms or signs (ie. dyspnea, asthenia, edema) with objective evidence of pulmonary or systemic congestion at rest or with exercise in the last 6 months. * Left ventricular ejection fraction \<50% confirmed by objective diagnostic methods (eg doppler echocardiogram). * Severe valvulopathies, confirmed by objective diagnostic methods (eg doppler echocardiogram). * Uncontrolled hyper or hypothyroidism. * Suprarenal insufficiency. * Previous surgeries in the last 3 months. * Severe trauma in the last 6 months, defined as one that involved bone fractures and/or surgical interventions. * Known active cancer disease or under treatment (acute or preventive), or history of cancer disease without criteria for cure. * Diagnosis of active autoimmune disease or a…