CompletedNot Applicable

Yoga Training and Retinal Vasculature With Parkinson's Disease

United States21 participantsStarted 2024-01-16

Plain-language summary

This study will compare the impact of a novel high-speed, cued yoga program to a standard yoga program on retinal microvasculature, cognition and neuromuscular function in persons with Parkinson's disease.

Who can participate

Age range

50 Years – 90 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Parkinson's disease (H\&Y 1, 2, and 3) confirmed by pretest administration of the UPDRS,
. 55-90 years of age,
. Montreal Cognitive Assessment \> 17.

Exclusion criteria

. Uncontrolled cardiovascular or neuromuscular diseases that prevent participation in a training program;
. cerebrovascular disease;
. documented HIV infection or other immunodeficiency syndrome;
. any systemic inflammatory or autoimmune conditions such as rheumatoid arthritis, systemic lupus erythematosus, or other serious concomitant medical illness;
. a history of ocular surgeries (except for cataract surgery more than 6 months ago) or other ocular diseases;
. bilateral moderate or severe cataracts;
. refractive errors of myopia, hyperopia and/or astigmatism more than 6.0 Diopters.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Changes in Retinal measured in microliters per second (ul/s)

Timeframe: Baseline, 24 weeks

Changes in Retinal vascular biomarkers

Timeframe: Baseline, 24 weeks

Changes in the Hopkins Verbal Learning Test

Timeframe: Baseline, 12 weeks, 24 weeks

Changes in Executive Function using the Dimensional Card Sort Test

Timeframe: Baseline, 12 weeks, 24 weeks

Changes in Executive Function using the Flanker Test

Timeframe: Baseline, 12 weeks, 24 weeks

Changes in Executive Function using the Picture Sequence Memory Test

Timeframe: Baseline, 12 weeks, 24 weeks

Changes in Executive Function using the List Sorting Test

Timeframe: Baseline, 12 weeks, 24 weeks

Trial details

NCT IDNCT06194227

SponsorUniversity of Miami

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-12-30

View on ClinicalTrials.gov More Cognitive Change trials

Who can participate

Age range

50 Years – 90 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Parkinson's disease (H\&Y 1, 2, and 3) confirmed by pretest administration of the UPDRS,
. 55-90 years of age,
. Montreal Cognitive Assessment \> 17.

Exclusion criteria

. Uncontrolled cardiovascular or neuromuscular diseases that prevent participation in a training program;
. cerebrovascular disease;
. documented HIV infection or other immunodeficiency syndrome;
. any systemic inflammatory or autoimmune conditions such as rheumatoid arthritis, systemic lupus erythematosus, or other serious concomitant medical illness;
. a history of ocular surgeries (except for cataract surgery more than 6 months ago) or other ocular diseases;
. bilateral moderate or severe cataracts;
. refractive errors of myopia, hyperopia and/or astigmatism more than 6.0 Diopters.

What they're measuring

Changes in Retinal measured in microliters per second (ul/s)

Timeframe: Baseline, 24 weeks

Changes in Retinal vascular biomarkers

Timeframe: Baseline, 24 weeks

Changes in the Hopkins Verbal Learning Test

Timeframe: Baseline, 12 weeks, 24 weeks

Changes in Executive Function using the Dimensional Card Sort Test

Timeframe: Baseline, 12 weeks, 24 weeks

Changes in Executive Function using the Flanker Test

Timeframe: Baseline, 12 weeks, 24 weeks

Changes in Executive Function using the Picture Sequence Memory Test

Timeframe: Baseline, 12 weeks, 24 weeks

Changes in Executive Function using the List Sorting Test

Timeframe: Baseline, 12 weeks, 24 weeks