RecruitingPhase 2

Communication Bridge 3 Study

United States200 participantsStarted 2024-08-23

Plain-language summary

This study will use a randomized controlled trial design to evaluate the effect of two evidence-based treatments for adults with mild-moderate Primary Progressive Aphasia (PPA). The aim of the study is to help us better understand the effects of speech-language therapy on communication abilities in individuals with PPA.

Who can participate

Age range

18 Years – 100 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Meets diagnostic criteria for PPA based on neurologist and supporting medical assessments (extracted from medical records)
. English as primary language used in daily communication activities (by self-report)
. Adequate hearing (aided or unaided) for communicating with others in a crowded room (by self-report)
. Adequate vision (aided or unaided) for reading a newspaper, or other functional materials (by self-report)
. Able to pass technology screening and demonstrates sufficient knowledge for use of video conference and Communication Bridge™ web application use (with or without training)
. Geriatric Depression Scale score ≤ 9
. Mild-moderate PPA informed by a structured interview with a speech-language pathologist and a standardized testing battery.
. 18+ years of age

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Change in Communication Participation Person Centered Goals

Timeframe: 5 assessment time points through study completion (up to 18 months)

Change in Communication Participation

Timeframe: 5 assessment time points through study completion (up to 18 months)

Montgomery Burden Inventory (MBI)

Timeframe: 5 assessment time points through study completion (up to 18 months)

Trial details

NCT IDNCT06191198

SponsorUniversity of Chicago

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2028-07-15

Contact for this trial

Matthew Bona, MPH

773-702-1220 cbtrial@uchicago.edu

View on ClinicalTrials.gov More Primary Progressive Aphasia trials

Plain-language summary

Who can participate

Age range

18 Years – 100 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Meets diagnostic criteria for PPA based on neurologist and supporting medical assessments (extracted from medical records)
. English as primary language used in daily communication activities (by self-report)
. Adequate hearing (aided or unaided) for communicating with others in a crowded room (by self-report)
. Adequate vision (aided or unaided) for reading a newspaper, or other functional materials (by self-report)
. Able to pass technology screening and demonstrates sufficient knowledge for use of video conference and Communication Bridge™ web application use (with or without training)
. Geriatric Depression Scale score ≤ 9
. Mild-moderate PPA informed by a structured interview with a speech-language pathologist and a standardized testing battery.
. 18+ years of age

What they're measuring

Change in Communication Participation Person Centered Goals

Timeframe: 5 assessment time points through study completion (up to 18 months)

Change in Communication Participation

Timeframe: 5 assessment time points through study completion (up to 18 months)

Montgomery Burden Inventory (MBI)

Timeframe: 5 assessment time points through study completion (up to 18 months)