Brief summary The goal of this study is to compare the effects of advanced platelet rich fibrin and enamel matrix derivative placed in the extraction alveoli of patients who had surgical removal of mandibular wisdom teeth. The questions it aims to answer/evaluate are: * postoperative pain, swelling, trismus, early wound healing using soft tissue healing index * level of early local inflammatory response by measuring levels of inflammatory mediators in wound exudate * degree of wound healing by measuring levels of early wound healing mediators in wound exudate * incidence of alveolar osteitis and delayed infection * levels of probing depth, clinical attachment loss, gingival margin level, bleeding on probing, gingival index, plaque index of the second mandibular molar 3 months after surgery Participants of the study will be asked: * for their preoperative clinical measurements (swelling, trismus, periodontal parameters) to be taken by the principal investigator * to provide 20 ml of venous blood if necessary * to preoperatively provide gingival crevicular fluid in the region of distal surface of the second mandibular molar and postoperatively wound exudate * to note the number of painkiller pills taken after surgery and pain levels in different time points * to come to regular checkups in which clinical measuring of postoperative swelling, trismus levels and periodontal parameters will be performed
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Evaluation of postoperative pain on visual analog scale
Timeframe: 24 hours after surgery
Evaluation of postoperative pain on visual analog scale
Timeframe: 24-48 hours after surgery
Evaluation of postoperative pain on visual analog scale
Timeframe: 48-72 hours after surgery
Evaluation of postoperative pain on visual analog scale
Timeframe: 72 hours- 7 days after surgery
Evaluation of postoperative pain on verbal rating scale
Timeframe: 24 hours after surgery
Evaluation of postoperative pain on verbal rating scale
Timeframe: 24-48 hours after surgery
Evaluation of postoperative pain on verbal rating scale
Timeframe: 48-72 hours after surgery
Evaluation of postoperative pain on verbal rating scale
Timeframe: 72 hours- 7 days after surgery
Evaluation of postoperative pain by marking the number of pain tablets and time of their consumption
Timeframe: 24 hours after surgery
Evaluation of postoperative pain by marking the number of pain tablets and time of their consumption
Timeframe: 24-48 hours after surgery
Evaluation of postoperative pain by marking the number of pain tablets and time of their consumption
Timeframe: 48-72 hours after surgery
Evaluation of postoperative pain by marking the number of pain tablets and time of their consumption
Timeframe: 72 hours- 7 days after surgery
Evaluation of preoperative tragus- oral commissure and outer eye canthus-angle of the mandible distances at the side of the extraction
Timeframe: 1 hour preoperatively
Evaluation of postoperative swelling
Timeframe: 24 hours after surgery
Evaluation of postoperative swelling
Timeframe: 48 hours after surgery
Evaluation of postoperative swelling
Timeframe: 72 hours after surgery
Evaluation of postoperative swelling
Timeframe: 7 days after surgery
Evaluation of preoperative maximal inter-incisor distance
Timeframe: 1 hour preoperatively
Evaluation of postoperative trismus
Timeframe: 24 hours postoperatively
Evaluation of postoperative trismus
Timeframe: 48 hours postoperatively
Evaluation of postoperative trismus
Timeframe: 7 days postoperatively
Relative gene expression of inflammatory and wound healing mediators in gingival crevicular fluid of the distal sulcus of the second mandibular molar preoperatively
Timeframe: 1 hour preoperatively
Protein expression of specialized pro-resolving inflammation mediator maresin 1 (Mar1) in gingival crevicular fluid of the distal sulcus of the second mandibular molar preoperatively
Timeframe: 1 hour preoperatively
Relative gene expression of inflammatory and wound healing mediators in wound exudate after surgical removal of impacted mandibular wisdom teeth
Timeframe: 48 hours postoperatively
Relative gene expression of inflammatory and wound healing mediators in wound exudate after surgical removal of impacted mandibular wisdom teeth
Timeframe: 7 days postoperatively
Protein expression of specialized pro-resolving inflammation mediator maresin 1 (Mar1) in wound exudate after surgical removal of impacted mandibular wisdom teeth
Timeframe: 48 hours postoperatively
Protein expression of specialized pro-resolving inflammation mediator maresin 1 (Mar1) in wound exudate after surgical removal of impacted mandibular wisdom teeth
Timeframe: 7 days postoperatively
Evaluation of soft tissue healing using Landry healing index
Timeframe: 7 days after surgery