Observational, randomized studies and their meta-analyses have shown the high effectiveness of high-flow oxygen therapy through nasal cannulas, reaching 50-60% in acute hypoxemic respiratory failure. Some bench studies showed the advantages of high-flow oxygen therapy compared with standard oxygen therapy, consisting in reducing the anatomical dead space and maintaining a given inspiratory oxygen fraction in the hypopharynx of the mannequin, but the actual state of the gas composition of the hypopharynx was not studied. The study aim is measurement of the inspiratory (FiO2) and expiratory (FeO2) fractions of oxygen, as well as the inspiratory (FiСO2) and expiratory (FeСO2) fractions of carbon dioxide in the hypopharynx of healthy volunteers during high-flow oxygen therapy through nasal cannulas in different physiological conditions.
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Inspiratory oxygen fraction (FiO2) in the hypopharynx
Timeframe: 5 minutes
Expiratory oxygen fraction (FeO2) in the hypopharynx
Timeframe: 5 minutes
Inspiratory fraction of carbon dioxide (FiCO2) in the hypopharynx
Timeframe: 5 minutes
Expiratory fraction of carbon dioxide (FeCO2) in the hypopharynx
Timeframe: 5 minutes