Researchers are looking for new ways to treat people with relapsed or refractory B-Cell Non-Hodgkin Lymphoma (B-NHL). B-cells are a type of white blood cells that make antibodies and help fight infections. Non-Hodgkin Lymphoma is a type of cancer in the lymphatic system causing enlarged lymph nodes and/or organs in belly or chest. Relapsed means a disease or condition comes back after treatment Refractory means a disease does not respond to treatment or stops responding to a treatment. MK-1045, the study medicine, is designed to treat relapsed or refractory B-NHL. MK-1045 is an immunotherapy, which is a treatment that helps the immune system fight cancer. This is the first study in which MK-1045 will be given to people. The goal of this study is to learn about: * The safety of MK-1045 and how well people tolerate it. * The highest dose of MK-1045 that is well tolerated. * How well MK-1045 works to treat relapsed or refractory B-NHL.
Age range
18 Years – 75 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Number of Participants who Experience a Dose-limiting Toxicity (DLT)
Timeframe: Up to ~28 Days
Number of Participants who Experience an Adverse Event (AE)
Timeframe: Up to ~15 months
Number of Participants who Experience a Serious Adverse Events (SAE)
Timeframe: Up to ~15 months
Number of Participants who Experience a Drug-related Adverse Event (DRAE)
Timeframe: Up to ~15 months
Number of Participants who Experience an AE of Grade 3 or higher
Timeframe: Up to ~15 months
Number of Participants who Experience an AE for Each Severity Grade from 1-5
Timeframe: Up to ~15 months
Number of Participants who Experience a SAE or Serious Drug-related AE
Timeframe: Up to ~15 months
Number of Participants who Experience a Dose Modification Due to an AE or DRAE
Timeframe: Up to ~15 months
Number of Participants who Withdraw from the Study due to an AE or DRAE
Timeframe: Up to ~15 months
Number of Participants who Died due to an AE or DRAE
Timeframe: Up to ~15 months