The goal of this clinical trial is to evaluate cardiometabolic and inflammatory parameters in kidney transplant recipients after transitioning to a plant-based diet (PBD). The main aims of the study are as follows:
* To test the feasibility of transiting renal allograft recipients who are \> 3 months post-transplant to a PBD
* To study the effect of a PBD on cardiometabolic parameters in kidney transplant recipients
* To assess the effect of a PBD on peripheral blood Th17/Treg ratio and systemic inflammation in kidney transplant recipients
Participants will be asked to:
* Complete a 2-week investigator-designed PBD transition program
* Follow a PBD for a minimum of 16 weeks
* Consent for blood draws, urine samples, and fecal samples along with physical exams
* Complete intermittent food frequency questionnaires and quality of life questionnaires
* Periodically meet with investigators and other study participants
Researchers will compare baseline measurements with future measurements for each participant.
Who can participate
Age range
18 Years – 80 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* \> 3 months post-kidney transplant
* On style immunosuppressive medication
* Without evidence of active infection/ inflammatory conditions
* Estimated glomerular filtration rate \> 45ml/min/1.73 m\^2
* English speaking
* Reliable internet access
Exclusion Criteria:
* Acute/ chronic allograft rejection
* History of non-compliance
* Advance heart failure
* Liver disease
* Pregnancy
* Malignancy
* Chronic Infection
* Currently following a plant-based diet
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is studying a plant-based diet in kidney transplant recipients and is no longer enrolling — are there similar dietary programs or nutrition-focused studies I could still participate in, or could we work with a dietitian to apply these principles to my care now?
2The trial is measuring inflammatory markers like IL-6, IL-17, and the Th17/Treg ratio — do my current lab results suggest that inflammation is something we should be actively targeting in my post-transplant care?
3Since this study tracks HbA1c, blood glucose, and cholesterol alongside transplant outcomes, how would shifting toward a more plant-based diet interact with my current immunosuppressant medications, and could it affect how well my transplanted kidney is doing?
4The trial monitors blood pressure closely in transplant recipients — given that hypertension is one of the conditions being studied, is my blood pressure currently at a level where a dietary change might make a meaningful difference, and what does my doctor think about that approach compared to adjusting my medications?
5Because this is listed as Phase NA and focuses on diet rather than a drug, what does my doctor think about the quality of evidence we can expect from a study like this, and how should that affect how seriously I consider its findings when making decisions about my own diet?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.