CompletedNot Applicable

Effects of High-intensity Exercise Training on Physical Fitness, Cognition, Language in Post-stroke Aphasia

United States12 participantsStarted 2023-12-11

Plain-language summary

The goal of this clinical trial is to establish the feasibility and fidelity of a high-intensity exercise program for individuals with post-stroke aphasia. The main questions it aims to answer are: * Is it feasible for stroke survivors with aphasia to participate in a long in-person physical exercise program? * Does participation in a physical exercise program lead to physical fitness, cognitive, language and/or psychological changes? Participants can take part in two different physical exercise interventions: * Low intensity intervention (control intervention); * High-intensity physical exercise intervention (target intervention).

Who can participate

Age range

18 Years – 80 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * aphasia following single or multiple ischemic or hemorrhagic stroke; * at least 6 months from the last stroke; * proficient in English before the stroke; * at least 8 years of education; * between the ages of 18 and 80; * independent with ambulation without a device (single-point cane accepted); * medically stable with no contraindications to participate in regular physical exercise as determined by the patient's own primary care provider or other treating provider. Exclusion Criteria: * prior history of dementia, neurologic illness (other than stroke), or substance abuse; * significant visual or hearing disabilities (e.g., neglect, uncorrected visual or hearing loss) that interfere with testing; * per self-report uncontrolled cardiorespiratory and/or metabolic disorders incompatible with exercise.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Change on the Western Aphasia Battery (WAB) - Aphasia Quotient

Timeframe: Baseline and immediately after the intervention (3rd week for the low-intensity arm and 9th week for the high-intensity arm)

Trial details

NCT IDNCT06185023

SponsorUniversity of California, Berkeley

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-09-12

View on ClinicalTrials.gov More Aphasia, Acquired trials