The encephalitis mediated by antibodies against the NMDA receptor (NMDARe) predominantly affects young adults and children resulting in severe neurologic and psychiatric deficits. After overcoming the acute stage, patients are left with long-lasting behavioral, cognitive, and psychiatric alterations with important socio-family-economical implications. Here investigators postulate that a better knowledge of this stage will improve treatment decisions and outcome. In Aim 1, the post-acute stage will be clinically characterized, tools to remotely follow cognitive, behavioral and psychiatric deficits will be provided, and the impact of cognitive rehabilitation will be assessed. In Aim 2, biomarkers (autoimmune, inflammatory, neuronal injury) will be identified as signatures of the acute and post-acute stages. In Aim 3, a mouse model of NMDARe will be used to determine the underlying mechanisms and treatment of the postacute stage.
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Age
Timeframe: 18 months
Gender
Timeframe: 18 months
Vision condition
Timeframe: 18 months
Handedness
Timeframe: 18 months
General medical history
Timeframe: 18 months
Allergies
Timeframe: 18 months
Symptoms related to NMDARe
Timeframe: 18 months
Treatments
Timeframe: 18 months
Functional status
Timeframe: 18 months
Intelligence Quotient
Timeframe: 18 months
Verbal working memory
Timeframe: 18 months
Phonological loop
Timeframe: 18 months
Visual working memory
Timeframe: 18 months
Verbal learning
Timeframe: 18 months
Proactive interference verbal memory
Timeframe: 18 months
Short-term verbal memory
Timeframe: 18 months
Long-term verbal memory
Timeframe: 18 months
Verbal recognition memory
Timeframe: 18 months
Verbal discrimination memory
Timeframe: 18 months
Verbal retention memory
Timeframe: 18 months
Immediate visual memory
Timeframe: 18 months
Delayed visual memory
Timeframe: 18 months
Visual retention memory
Timeframe: 18 months
Visual recognition memory
Timeframe: 18 months
Visual discrimination memory
Timeframe: 18 months
Processing speed
Timeframe: 18 months
TMT-A
Timeframe: 18 months
TMT-B
Timeframe: 18 months
Naming
Timeframe: 18 months
Naming with cues
Timeframe: 18 months
Latency in naming
Timeframe: 18 months
Semantic fluency
Timeframe: 18 months
Phonemic fluency
Timeframe: 18 months
Visuospatial skills
Timeframe: 18 months
Visuospatial skills - children
Timeframe: 18 months
Stroop test - word subtest
Timeframe: 18 months
Stroop test - color subtest
Timeframe: 18 months
Stroop test - word-color subtest
Timeframe: 18 months
Detectability - CPT3
Timeframe: 18 months
Omissions - CPT3
Timeframe: 18 months
Comissions - CPT3
Timeframe: 18 months
HRT - CPT3
Timeframe: 18 months
HRT-SD - CPT3
Timeframe: 18 months
Variability- CPT3
Timeframe: 18 months
HRT Block Change - CPT3
Timeframe: 18 months
HRT ISI Change - CPT3
Timeframe: 18 months
Prensence of psychiatric symptoms or disorders in presential assessments
Timeframe: 18 months
Sleep microstructure - Total study time
Timeframe: 18 months
Sleep microstructure - Total sleep time
Timeframe: 18 months
Sleep microstructure - Sleep efficiency
Timeframe: 18 months
Sleep microstructure - Time to sleep onset
Timeframe: 18 months
Sleep microstructure - Time in stage N1
Timeframe: 18 months
Sleep microstructure - Time in stage N2
Timeframe: 18 months
Sleep microstructure - Time in stage N3
Timeframe: 18 months
Sleep microstructure - Time in stage R
Timeframe: 18 months
Sleep microstructure - First epoch of N1
Timeframe: 18 months
Sleep microstructure - First epoch of N2
Timeframe: 18 months
Sleep microstructure - First epoch of N3
Timeframe: 18 months
Sleep microstructure - First epoch of REM
Timeframe: 18 months
Sleep microstructure - REM/NREM time ratio
Timeframe: 18 months
Sleep microstructure - Number of arousals
Timeframe: 18 months
Sleep microstructure - Arousal Index
Timeframe: 18 months
Sleep microstructure - Confusional arousals
Timeframe: 18 months
Sleep microstructure - Direct transition from N3 to W
Timeframe: 18 months
Sleep microstructure - Delta arousals
Timeframe: 18 months
Sleep microstructure - Wake after sleep
Timeframe: 18 months
Adherence to cognitive treatment - 6 months
Timeframe: 6 months
Adherence to cognitive treatment - 9 months
Timeframe: 9 months
Adherence to cognitive treatment - 12 months
Timeframe: 12 months